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Veterinarian Technician December 2009 (Vol 30, No 12)

Insulin Receives FDA Approval

    ST. JOSEPH, MO — Boehringer Ingelheim Vetmedica Inc. (BIVI) has announced that ProZinc (protamine zinc recombinant human insulin) has been approved for veterinary use by the FDA. ProZinc is an aqueous protamine zinc (PZI) suspension of recombinant human insulin that is used to reduce hyperglycemia in cats with diabetes mellitus.

    According to Kurt Peterson, DVM, technical veterinarian with BIVI, ProZinc is the first recombinant human PZI insulin available for the management of feline diabetes mellitus. "Extensive research has demonstrated that ProZinc is safe and effective for controlling hyperglycemia in newly diagnosed cats and diabetic cats that have not responded well to previous treatment therapies.1"

    In addition, Peterson said the research shows that ProZinc provides consistent absorption with long duration of action, which results in consistent and predictable blood glucose control in diabetic cats.1

    "Because ProZinc is a protamine zinc recombinant human insulin, it offers some key advantages. First, recombinant technology is not subject to the raw material sourcing challenges seen with animal-source insulin products. Second, the protamine and zinc formulation of ProZinc provides a long duration of effect."

    Practitioners and cat owners who have used PZI-VET in the past should find this product to be comparable in potency, onset, and duration of glycemic control.2

    ProZinc should be administered with a U-40 insulin syringe and has an initial recommended dose range of 0.1-0.3 IU insulin/lb of body weight every 12 hours. ProZinc will be available for sale to veterinarians beginning Nov. 16, 2009. Veterinarians should contact their distributor or BIVI representative for more details and product availability. For more information, visit www.ProZinc.us.

    1. Nelson RW, Henley K, Cole C. Field Safety and Efficacy of PZIR for Treatment of Diabetes Mellitus in Cats. JVIM. 2009;23:787-793.

    2. Norsworthy GD, Lynn R, Cole C. Preliminary Study of Protamine Zinc Recombinant Insulin for the Treatment of Diabetes Mellitus in Cats. Vet Ther. 2009;10:24-28.

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