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Care Guide

About Care Guides[x] These care guides are written to help your clients understand common conditions, tests, and procedures, as well as to provide basic information about pet care. They are based on the most up-to-date, documented information, recommendations, and guidelines available in the United States at the time of writing. Pharmaceutical product licensing, availability, and usage recommendations are based on US product information. Use the Download Handout button to generate a PDF for printing or e-mailing to your clients.

Diabetes Insipidus in Cats

    • Diabetes insipidus occurs when the body is unable to produce an adequate amount of the hormone vasopressin (also called anti-diuretic hormone [ADH]).
    • Affected cats drink excessively because they lose excessive amounts of fluid through urination.
    • With treatment, cats with diabetes insipidus can live a normal life span and enjoy a relatively normal life.

    What Is Diabetes Insipidus?

    When most of us think about diabetes, we think of a condition called diabetes mellitus. This is a disease in which the body doesn’t make an adequate amount of the hormone insulin or the body is unable to use its available insulin effectively. The result is an inability to regulate the body’s blood sugar level.

    However, there is another form of diabetes called diabetes insipidus. Like diabetes mellitus, diabetes insipidus involves changes in one of the body’s hormone levels. Diabetes insipidus occurs when the body is unable to produce an adequate amount of the hormone vasopressin (also called anti-diuretic hormone [ADH]) or when the available vasopressin is not being used properly.

    Normally, ADH is produced by the brain, enters the bloodstream, and affects several areas of the body, particularly the kidneys. ADH helps the kidneys retain water, which is necessary for keeping the body adequately hydrated. Diabetes insipidus occurs when the body doesn’t have enough ADH or when the kidneys can’t use it properly. The result is fluid loss by the body, leading to dehydration.

    Because ADH is produced in the brain, medical conditions such as brain injury, brain inflammation, and brain tumors can sometimes interfere with the brain’s ability to produce a normal amount of the hormone. Conditions that can reduce the kidney’s ability to use ADH properly in cats include uterine and kidney infections.

    What Are the Clinical Signs of Diabetes Insipidus?

    Because ADH helps the body retain water, an inadequate amount of ADH (or an inability to use it properly) causes the body to lose too much water through urine production by the kidneys. A very common clinical sign associated with diabetes insipidus is increased production of abnormally dilute urine. The pet responds to this water loss (dehydration) by drinking more water, so cats with diabetes insipidus tend to urinate frequently and drink large amounts of water. Affected cats may also urinate outside the litterbox or use much more litter than normal.

    In some cases, the cat may be so desperate for water that he or she stops eating (preferring instead to drink even more water) and begins to lose weight. Some cats also “steal” water from various sources around the home.

    How Is Diabetes Insipidus Diagnosed?

    Your veterinarian will begin the diagnostic process by obtaining a thorough medical history from you and performing a physical examination on your cat. Initial diagnostic tests may include a chemistry panel, a CBC (complete blood cell count), a thyroid hormone test, and urinalysis. These tests can help rule out kidney disease, thyroid disease, diabetes mellitus, and other medical conditions that tend to make cats drink more water and urinate excessively. If there is an underlying medical condition that may be causing diabetes insipidus, such as uterine or kidney infection, investigation of the underlying problem will likely be part of the diagnostic process. 

    Additional testing for diabetes insipidus may include additional blood testing and urinalysis as well as performance of a specific test to determine if your cat’s kidneys are able to produce concentrated urine. This test may require that your cat spend a day or more in the hospital. As part of the diagnostic plan, some veterinarians administer desmopressin (a synthetic replacement for ADH) to measure how the patient responds to ADH replacement.

    Your veterinarian will evaluate your pet and discuss diagnostic testing options with you. 


    Synthetic ADH substitutes are available for use in cats. Some of these agents are administered by injection, but some formulations are administered as drops into the eyes or nose. Weaning the pet onto a sodium-restricted diet may also be part of the recommended therapy for diabetes insipidus.

    Some pet owners may elect not to treat diabetes insipidus. In this case, the pet must have unrestricted access to water at all times. If water is restricted in any way, the pet can quickly become dehydrated and suffer life-threatening complications. Also, the home environment and daily routine must be modified to allow for frequent urination. This may include purchasing additional litterboxes and changing them more frequently.

    With treatment, cats with diabetes insipidus can live a normal life span and enjoy a relatively normal life. An untreated cat can also do very well, as long as plenty of water is always available.