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Compendium September 2008 (Vol 30, No 9)

Veterinary Therapeutics Selected Abstract: Pharmacokinetics of Buprenorphine Following Intravenous and Oral Transmucosal Administration in Dogs

by Sara M. Cowan, DVM, Susan E. Bunch, DVM, PhD, DACVIM

    Abbo LA, Ko JCH, Maxwell LK, et al. Vet Ther 2008;9(2):83-93.

    Pharmacokinetic analysis of buprenorphine administered to six healthy dogs via the oral transmucosal (OTM) route at doses of 20 and 120 µg/kg was conducted using liquid chromatography"electrospray ionization"tandem mass spectroscopy (LC-ESI-MS/MS). Bioavailability was 38% ± 12% for the 20 µg/kg dose and 47% ± 16% for the 120 µg/kg dose. Maximum plasma concentrations were similar for buprenorphine doses of 20 µg/kg IV and 120 µg/kg OTM. Sedation and salivation were common side effects, but no bradycardia, apnea, or cardiorespiratory depressive effects were seen. When the two OTM dosing rates were normalized to dose, LC-ESI-MS/MS analysis of buprenorphine and its metabolites detected no significant difference (P > .05), indicating dose proportionality. The results of this study suggest that OTM buprenorphine may be an alternative for pain management in dogs.

    Click here to read the complete article from the Summer 2008 issue of Veterinary Therapeutics.

    This study was funded by the Purdue University School of Veterinary Medicine. Buprenorphine and metabolite determinations were partially funded by NIH grant RO1-DA10100.

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