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Compendium November 2008 (Vol 30, No 11)

Veterinary Therapeutics Selected Abstract — Comparative Adrenocortical Suppression in Dogs with Otitis Externa Following Topical Otic Administration of Four Different Glucocorticoid-Containing Medications

    Reeder CJ, Griffin CE, Polissar NL, et al. Vet Ther 2008;9(2):111-121.

    The safety of using otic formulations is often of concern for practitioners and pet owners alike, with "safe" in this context meaning no adrenocortical suppression. This study evaluated the effect of four glucocorticoid-containing otic formulations on plasma cortisol concentrations, measured by corticotropin stimulation testing (plasma cortisol concentrations before and after corticotropin injection), in dogs presented with otitis externa. Dexameth­asone tended to have greater adrenocortical suppression compared with the other three formulations (betamethasone, triamcinolone, and mometasone), but the difference was not statistically significant. The largest difference among the four drugs was observed between dexamethasone and betamethasone (P = .09).

    Click here to read the complete article from the Summer 2008 issue of Veterinary Therapeutics.

    *This study was funded by Intervet/Schering-Plough Animal Health, Summit, NJ.

    NEXT: Abstract Thoughts — Clinical and Imaging Evaluations of Ischemic Myelopathy

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